Cellular mechanism may explain uneven response to cancer treatment
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A new study has identified a cellular mechanism that may help explain why some patients respond to certain cancer treatments while others see weaker results from the same drug. The researchers found that the issue is not only whether the drug reaches the tumour, but also how it is distributed within the tumour and inside individual cancer cells.
The study focused on PARP inhibitors, a class of targeted therapies used in some ovarian cancers and also in certain breast and prostate cancers. The findings suggest that some of these drugs can accumulate inside lysosomes, creating slow-release reservoirs that lead to uneven drug exposure across tumour cells.
Using advanced imaging and molecular analysis, the team studied living slices of patient-derived ovarian tumours in the lab. The researchers found that drug distribution varied widely across tumour regions, and that this pattern was seen with drugs such as rucaparib and niraparib, but not in the same way with olaparib.
The team said the findings could eventually support more personalised treatment strategies, but cautioned that the work remains early-stage because it was carried out on tumour tissue outside the body rather than in direct clinical trials involving patients.
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Tahani Elghazaly5252 Posts
